A weight loss breakthrough.

Recent scientific discoveries offer insight into how our hormones and body change over time — and how that impacts whether we’ll gain or lose weight. It comes down to the relationship between our brains and our guts.

A new family of medications called GLP-1s address these biological factors head-on. 


It’s about more than willpower. It’s biology.

Biological factors including genetics and other health conditions can make weight loss even more difficult. The environment around us can also play a big role in weight loss.

GLP-1s fight back against these genetic, biological, and environmental factors that prevent weight loss.

244 genes

linked to obesity

40-70% of weight gain

is linked to genetics

* According to a 2007 study from the Canadian Journal of Cardiology.


How GLP-1s Work


A naturally occurring hormone

GLP-1 is naturally released by the gut in response to food.


An extra boost for your system

The effects include increasing insulin release from the pancreas, slowing down stomach emptying, and targeting receptors in the brain that cause appetite reduction.


A more efficient weight loss outcome

This results in a sensation of satiety, or fullness, lasting much longer than possible with natural GLP-1 hormone levels.


Effective medications for weight loss

The weight management medications our clinicians might use in your treatment plan include GLP-1s like Wegovy and Saxenda.


Wegovy (Semaglutide)

Wegovy is the brand name for a GLP-1 medication called Semaglutide. It was FDA-approved for obesity treatment in 2021.

In a placebo-controlled trial of adults without diabetes, those who received Wegovy lost an average of 15% of their initial body weight.


Saxenda (Liraglutide)

Saxenda is the brand name for the GLP-1 medication Liraglutide. It was FDA-approved in 2014 for weight loss.

In a 56-week study, 63.2% of patients taking Saxenda lost at least 5% of their body weight (compared with 27.1% in the placebo group who did the same).



Metformin is a generic medication that is FDA-approved for type II diabetes but sometimes used off-label for weight loss. It is generally more affordable for patients without insurance coverage. The cost of Metformin is included in your Sequence membership.

There are multiple studies exploring Metformin for weight loss and obesity treatment. One study from 2013 found Metformin to be effective for weight loss, particularly in those with insulin resistance. Similarly, other researchers have found Metformin to be effective for weight loss in patients with PCOS.


Other medications

Your Sequence Clinician may determine that another medication or a combination of medications might work best for your medical history and biology. They will do a careful review of your specific case to ensure you’re getting an effective medication that meets your needs.

You can learn more about different medications, common side effects, and their results and costs, by visiting our blog.

What does it feel like to be on a GLP-1?


By managing appetite, cravings, and blood sugar, GLP-1s help you maintain healthy habits. Prescription weight loss medications also give some members more energy and motivation.

“It curbs my appetite and cravings...It truly gives me willpower I am unable to formulate on my own!”


“It's a new feeling to not always feel hungry.”


“I'm finally back in the right direction.”


Beyond the medications—comprehensive support

GLP-1s are meant to be used in conjunction with lifestyle changes. That’s why we include dietitian and fitness visits in every Sequence membership.

You don’t have to do it alone. Your dedicated Care Team is there every step of the way to provide support, answer questions, and help with any issues you might have.


Get off the weight loss roller coaster

On average, Sequence members lose 15% of their body weight after being on the program for 26 weeks.*

See how much you can lose in 12 months:

Average weight after 12-months:
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*Based on 5,377 members who have been on the Sequence program for at least 26 weeks. Average reported body weight lost was 15.17% and the top quartile lost an average of 19.90% of body weight.

What the research says

Some of the world’s most respected publications have a few things to say about GLP-1 medications. Check it out for yourself.

“Results could mark a "new era" in treating obesity with even more therapies on the horizon."
"In studies, a weekly injection caused dramatic amounts of weight loss and improved other heart-related risk factors."
"2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight."
“The most effective drug intervention we have seen for weight management."
"These highly effective anti-obesity medications are associated with weight losses of more than 10% of overall bodyweight in more than two-thirds of clinical trial participants."
"3.0 mg of liraglutide, as an adjunct to diet and exercise, was associated with reduced body weight and improved metabolic control."

Weight loss medication FAQs

Learn more about these powerful tools.

Do you need to have diabetes to take GLP-1s?
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Are there generic options for GLP-1s?
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Hear from real Sequence members.

They beat their weight loss plateaus with Sequence's comprehensive program.